Mitochondria in IVF

Mitochondria play a vital role in oocyte functions and they are critical an indicator of oocyte quality. It is important for fertilization and development into viable offspring. Quality-compromised oocyte is correlated with the infertility, developmental disorders, reduced blastocyst cell number and embryo loss in mitochondrial dysfunctions plays a significant role. Increasingly, women affected with metabolic disorders such as diabetes or obesity and oocyte aging are seeking treatment in IVF clinics to overcome the adverse effect of metabolic conditions on mitochondrial functions and new treatments have become available to restore oocyte quality. A new technology has opened up new possibilities for therapeutic advances which will increase the success rates for IVF of oocytes from women with compromised oocyte quality. Among this, the major mitochondrial functions are the production of adenosine triphosphate (ATP) to provide energy. Compared to mitochondria in the somatic cells, little is known about mitochondria in oocytes and in the preimplantation embryo but it is well known that the mitochondrial dysfunction in oocyte and an embryo plays significant role in infertility and in developmental abnormalities.

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