Call for Abstract
2nd World Congress on Embryology and In Vitro Fertilization, will be organized around the theme “Exploring the Novel Research & Techniques in Reproductive Health”
In Vitro Fertilization 2018 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in In Vitro Fertilization 2018
Submit your abstract to any of the mentioned tracks.
Register now for the conference by choosing an appropriate package suitable to you.
Artificial insemination (AI) is that the deliberate introduction of sperm cell into a female's womb or cervix for the aim of achieving a physiological condition through in vivo fertilization. It is a fertility treatment for humans, and could be applied in animal breeding also. Artificial insemination could use motor-assisted fruitful technology, sperm cell donation and agriculture techniques. Insemination techniques on the market can be done by intracervical insemination and intrauterine insemination. The beneficiaries of insemination are ladies who need to convey birth to their own kid, who could also be in a very lesbian relationship, single ladies or ladies who are in a very heterosexual relationship but male partner suffers from male sterility. Intracervical insemination (ICI) is that the best and most typical insemination technique and might be utilized in the house for self-insemination without any caregiver help. Compared with natural insemination (i.e., insemination by sexual intercourse), artificial insemination will be costlier and additional invasive, and needs skilled help.
In vitro fertilization (IVF) treatment is complex series of procedures used for fertility treatment or genetic problems and assist with the conception of a child. During in vitro fertilization, mature eggs were collected from ovaries and fertilized by sperm in a lab conditions. In vitro fertilization is the most effective form of assisted reproductive technology. During in vitro fertilization, eggs and sperm are brought together in laboratory glass dish to allow the sperm to fertilize an egg. Using in vitro fertilization, one can use any combination like own eggs and sperm or donor eggs and sperm. After in vitro fertilization, one or more fertilized eggs are placed in the uterus.
Frozen embryo transfer (FET) is a cycle where a frozen embryo of previous fresh IVF cycle is softened to liquid and transferred back into the woman's uterus. This means it doesn’t undergo another cycle of hormone stimulation and an egg collection .This cycles can be undertaken on natural cycle by using hormone preparation or ovulation induction. Embryo freezing gives more opportunities for pregnancy for each hormone stimulation cycle and egg collection. Frozen embryos are viable to the infinite time after the first freeze. Embryo transfer can be done either after a successful or unsuccessful in vitro fertilization due to their infinite viability. Freezing embryos previously was a very slow process. But now, the applications were changes and freezing was done by a very simple and easy method called vitrification (freezing of embryos using cutting edge technology).
In female fertility surgery following are the initial testing and assessment that a fertility specialist may recommend. It involves the laparoscopy, surgery of endometriosis, surgery for Fallopian tubes, female micro surgery. This can be used for further investigating the cause of infertility or to overcome the problems making it difficult to conceive.
Assisted hatching is an advanced scientific technique which involves using a laser to gently thin the outer shell of the egg. In some cases, particularly in older women, the thickness of the outer shell is implantation if an embryo hatches out of the shell more easily, in such cases it may have a better chance of implanting inside the uterus. If they have 38 years of age and had an unsuccessful IVF treatment cycle, then recommend using Assisted Hatching.
Assisted hatching is a scientific technique used in In Vitro Fertilization, which improves implantation of embryos into woman’s uterine lining by creating an opening through which embryonic cells hatches out. Pregnancy doesn’t occur unless embryo hatches. Before embryo implantation, developing embryo must hatch out of its outer shell named as zona pellucida. Some embryos seem to have thicker shell that may decrease their ability to hatch and therefore reduce likelihood that they will implant. This may be due to age of woman or other, unknown reasons. The unfertilized egg is surrounded by zona pellucid. Zona pellucida allows only one sperm cell to enter and fertilizes egg. After fertilization, embryo begins to cleave into two, four and so on. Assisted hatching is performed on embryos at this early cleavage stage. Women aged >37 have tendency to produce oocytes with harder or thicker zona pellucida compared to younger women. Same applies to women with high level of follicle-stimulating hormone.
Pre implantation genetic diagnosis with Karyomapping is a highly sophisticated scientific technique which can test embryos for presence of a single gene disorder. This allows selection of embryos which are not affected by a specific disorder for embryo transfer during an IVF cycle, preventing the condition from being passed on to any future children. In vitro fertilization (IVF) is essential to carry out PGD. This process involves collecting several eggs from the ovaries and fertilizing them outside the body (in vitro) to produce several embryos. Each of the embryos can then be tested to find out which is healthy. Only embryos that are predicted to be free of genetic condition are transferred to the uterus and consequently if any pregnancy that begins has a low risk of being affected by disorder.
PolScope or Oosight Technology is an advanced scientific technique that uses polarized light to study the genetic material in the egg and help to identify which eggs may have a better chance of implanting. It may also help with the ICSI process, as the scientist performing the procedure to see where the genetic material is located to avoid injecting through this spindle.
IVM is the technique of permitting the ovarian follicles and the oocytes inside the mature in vitro. It can be offered to women with infertility problems combined with IVF, offering women pregnancy without ovarian stimulation. The obstetric and perinatal outcome of births from IVM cycles is similar to those with ICSI treatments. However, IVM involves the use of invasive techniques, and this can harm the mother.
Assisted reproductive technology (ART) is a treatment used for infertility. It includes fertility treatments that handle both woman's egg and man's sperm. It works by removing eggs from woman's body. Eggs are then mixed with sperm to produce embryos. Embryos are then placed in woman's body. In vitro fertilization (IVF) is most common and effective type of assisted reproductive technology. Assisted Reproductive Technology includes in vitro fertilization-embryo transfer, gamete intrafallopian transfer, zygote intrafallopian transfer, and frozen embryo transfer. Approximately 99% of ART cycles performed are in vitro fertilization-embryo transfer. In vitro fertilization-embryo transfer helped many couples to conceive successfully. Assisted Reproductive Technology can be recommended when other fertility treatments were not successful or when there is severe male factor infertility, severe endometriosis or tubal obstruction.
The main function of human reproduction is mainly influenced by age to produce sex cells and hormones. Aging process affects reproductive systems of both men and women. The most striking age related changes in female reproductive system occur at menopause, while changes in the male reproductive system occur more gradually over a longer period of time. Despite this, a modern technology has been unable to extend the reproductive system in women, and the age of onset of menopause remains remarkably constant. Although many factors contribute to the age-related decline in human fertility, data suggested that the maternal aging renders the most significant impact.
Cryopreservation or cryoconservation is a method where organelles, cells, tissues, animate thing matrix, organs or the other biological constructs liable to injury caused by unregulated chemical mechanics are preserved by cooling to terribly low temperatures. At low temperatures, any protein or enzymatic activity may cause injury to biological material which is effectively stopped. Cryopreservation strategies look forward to achieve low temperatures without changing further injury caused by formation of ice throughout phase change. Ancient cryopreservation has relied on coating fabric to be frozen with category of molecules termed cryoprotectants. New strategies are perpetually being investigated owing to inherent of many toxic cryoprotectants. By default, it ought to be thought of that cryopreservation alters or compromises the structure and performance of cells unless it's established otherwise for a specific cell population. Cryoconservation of animal genetic resources is that method during which animal genetic material is collected and kept with intention of conservation of breed.
Polycystic ovary syndrome (PCOS) could be a set of symptoms because of elevated androgens (male hormones) in girls. Signs and symptoms of PCOS include irregular or no discharge periods, serious periods, excess body and facial hair, acne, girdle pain, issue obtaining pregnancy, and patches of thick, darker, velvety skin. Associated conditions include a pair of polygenic disease, obesity, preventative apnea, cardiovascular disease, mood disorders, and carcinoma. PCOS is because of a mix of genetic and environmental factors. Risk factors include fleshiness, not enough workouts, and a case history of somebody with the condition. Diagnosing relies on 2 of the subsequent 3 findings: no organic process, high steroid hormone levels, and sex gland cysts. Cysts could also be detectable by ultrasound. Different conditions that turn out similar symptoms include adrenal dysplasia, gland disease, and hyperprolactinemia.
Histopathology is the microscopic examination of tissues to study manifestation of diseases. Histopathology can also be done in embryos. Embryo histopathology is study of abnormal embryos or defectively developing embryos. It can be done in various ways like necropsy, autopsy, biopsy, checking for separation of eyelids, checking for presence of fingerprints, length of the embryo, external body form of the embryo, X-ray of the embryo, abnormalities of specific systems (central nervous system, cardiovascular system, musculoskeletal system, urogenital system, morphological disturbances in chromosomal abnormalities, metabolic abnormalities). The exact frequency for pathogenesis of congenital defects can be obtained only by the examination of embryo. However, some of the pathological disturbances can also be obtained from maternal examination.
Implantation takes place, when ovulation and fertilization occur. Implantation happens in early stage of pregnancy when the fertilized egg (zygote) travels down the fallopian tube to the uterus and attaches to the epithelium or uterine lining. It takes about 8 to 10 days for the fertilized egg to reaches to the uterus. During this time, it develops into a blastocyst through different stages of transformation beginning as a single cell dividing into 150 cells with an outer layer the trophoblast, a fluid-filled cavity the blastocoel, and a cluster of cells on the interior the inner cell mass. The tiny ball of cells is about a size of a poppy seed. It attaches to the epithelium during 4th week of gestation. Once it is firmly adheres, this is called as an embryo. The embryo then again divides into two parts which will become the placenta and the fetus. An ultrasound done during the 5 to 6 weeks of gestation period that may show the amniotic sac and yolk sac, which are forming during this time. The amniotic sac is where baby will develop. The yolk sac will later be incorporated in a baby’s digestive tract. This ultrasound confirms that implantation has taken place.
- Track 15-1Abnormal implantation
- Track 15-2Ovulation implantation
- Track 15-3Growth and implantation
- Track 15-4Implantation bleeding
- Track 15-5Blastocyst formation
Complications from the premature birth are to blame for the deaths of a third of the babies who die before their first birthday, As according to a new study on infant mortality, the study also shows that black women are more likely to lose their first babies to death as if they give birth in their late 20s rather than as teenagers. Both findings are contrary to conventional wisdom about the causes of infant mortality and its relationship to the teenage pregnancy. As pregnant women with periodontal disease are more likely to deliver a premature baby, we have made significant progress in learning that how to keep premature babies alive and well, but still there is less research that helps us to learn what causes premature birth. A Little progress has been made in improving the long-term health of the extremely premature babies and with pre-term births on the rise across Europe, rates of serious disability are more likely to increase. A decade of advances in medicine mean more babies are born at between 22 and 26 weeks gestation manage to survive, but the rates of severe health complications remain as high as they were in 1995.Important growth and development happens throughout pregnancy.
- Track 16-1Adult premature aging syndrome
- Track 16-2Premature birth
- Track 16-3Developmental delay
- Track 16-4Breathing problems
- Track 16-5Feeding difficulties
- Track 16-6Vision problems
- Track 16-7Hearing problems
Designing an IVF Laboratory requires experts skill and training. ART Laboratory is a resource for infertility and reproductive professionals. IVF Laboratories has become an integral part of all infertility and fertility clinics all over world. Infertility specialist planning for all to open new IVF units, setting up an ideal laboratory is the key to success in IVF. To design, built and setting up complete world class IVF center or lab it is important turnkey project and we need an expert to take care of it. While setting up a state-of-the-art IVF lab one need to keep in mind experience of Fertility specialists, Fertility embryologists and the scientists who are the key factors for the IVF lab. Needs help to plan and design lab space that best fit for clinic. Every lab has its own unique features. It is important to understand the type of work being done in the room and the work flow within the room. IVF lab design specialists will work to plan lab work flow and help best place hood, incubators and micro-manipulator. Setting up of ideal IVF laboratory includes IVF Lab Infrastructure.
- Track 17-1Fornax series
- Track 17-2Accessories
- Track 17-3Cryo Accessories
- Track 17-4Incubators
- Track 17-5Sperm fugue
- Track 17-6Micromanipulators And Inverted Microscopes
Fertilization (IVF) program. In most of the IVF clinics around the world, this quality assessment a precise embryo quality evaluation is of paramount importance to sustain successful in vitro relies mainly on morphological evaluation of cleavage stage embryos. Embryologists should able to correlate with the features observed at the optical microscopes with the implantation potential of each particular embryo .To achieve this goal, many of the scoring systems are based on the morphological features of dividing embryo have been developed. These embryo classification systems are based on the evaluation of number of blastomeres, degree of fragmentation, the symmetry of the blastomeres, the presence of multinucleation and the compaction status. It is very important that the features that are related to the implantation potential are assessed accurately and similarly. The purpose for this is to illustrate morphological aspects useful for evaluation of the implantation potential of embryos. Cleavage stage embryos are ranges from the 2-cell stage to the compacted morula composed of 8–16 cells. After embryo reaches 8-cell stage, the blastomeres begins to show an increase in cell. Adherence of cell is due to the spread of intercellular tight junctions.
- Track 18-1Blastomere size
- Track 18-2Cell numbers
- Track 18-3Compaction
Approximately 13-15% of couples will encounter fertility problems during the reproductive life. Factors involving males are responsible for infertility in approximately 20% of couples and are contributory in another 30–40% of couples. This means that factors Involving males and infertility are implicated in more than 50% of the difficulties couples encounter when attempting pregnancy .Diagnostic tools and therapies to treat female infertility are relatively well developed. However, many of the causes of male infertility are considered idiopathic. The spermogram is accurately assesses male fertility through an evaluation of the semen quality, sperm concentration, motility and morphology. The normal spermogram values were based on the multi-centered population studies on fertile men. However, several men presenting normal spermogram values are diagnosed as idiopathically infertile. These men may present with post-testicular defects that result in ejaculation of spermatozoa with a normal morphology but with a sub-optimal fertilization Capacity. The epididymis could be particularly involved in a number of Pathophysiology’s affecting the sperm maturation in some of these cases of male infertility.
Mitochondria play a vital role in oocyte functions and they are critical an indicator of oocyte quality. It is important for fertilization and development into viable offspring. Quality-compromised oocyte is correlated with the infertility, developmental disorders, reduced blastocyst cell number and embryo loss in mitochondrial dysfunctions plays a significant role. Increasingly, women affected with metabolic disorders such as diabetes or obesity and oocyte aging are seeking treatment in IVF clinics to overcome the adverse effect of metabolic conditions on mitochondrial functions and new treatments have become available to restore oocyte quality. A new technology has opened up new possibilities for therapeutic advances which will increase the success rates for IVF of oocytes from women with compromised oocyte quality. Among this, the major mitochondrial functions are the production of adenosine triphosphate (ATP) to provide energy. Compared to mitochondria in the somatic cells, little is known about mitochondria in oocytes and in the preimplantation embryo but it is well known that the mitochondrial dysfunction in oocyte and an embryo plays significant role in infertility and in developmental abnormalities.
Embryo transfer refers the process of assisted reproduction in this embryos are placed into the uterus of a female with the intent to establish a pregnancy. This technique which is often used with in vitro fertilization (IVF), may be used in humans or in animals. Single embryo transfer significantly reduces the incidence of multiple pregnancies. Surprisingly, a case of heterotopic pregnancy experienced after a single embryo transfer caused by coincidental natural pregnancy during assisted reproductive technologies. An infertile woman, during her natural cycle transfer a single embryo which cryopreserved for 3 years found to be heterotopically pregnant. After an early and successful management with laparoscopic right salpingectomy, finally reached at full-term vaginal delivery.
Embryo culture confers different stages of embryogenesis at embryo transfer. The main stages at which embryo transfer is performed are cleavage stage or the blastocyst stage .Embryo culture until the blastocyst stage gives a significant increase in live birth rate per embryo transfer, but also gives a decreased number of embryos available for transfer and embryo cryopreservation, the cumulative clinical pregnancy rates is increased with cleavage stage transfer. Transfer day 2 instead of day 3 after fertilization will have no differences in rate. Embryos culture can be performed in an artificial culture medium or in an autologous endometrial co culture. With artificial culture medium, there either be same culture medium throughout the period, or a sequential system will be used, in this embryo is sequentially placed in different media. Artificial embryo culture media contain glucose, pyruvate, and energy-providing components, as the addition of amino acids, nucleotides, vitamins, and cholesterol improve the performance of embryonic growth and development. Methods to permit dynamic embryo culture with fluid flow and embryo movement is also available. A new method in the development uses the uterus as an incubator and naturally occurring intrauterine fluids as culture medium by encapsulating embryos in a permeable intrauterine vessel. IVF culture media was unable to identify a specific media that was superior in terms of pregnancy outcome. Low oxygen usage concentrations of 5% rather than about 20% in the atmosphere is shown to increase live birth rate to a relative probability of 1.24, without any evidence of increased risk for multiple pregnancies, miscarriages and congenital abnormalities.
Vitrification is a technology used in the embryo and egg freezing process so that they can be stored for later use. This technology has many uses outside of fertility care with egg and embryo freezing, it allows something with a crystalline structure to converted into something very smooth. Cryobiology has come up with 2 methods that work well with human embryos, slow freezing and vitrification. Oocyte vitrification is followed by intracytoplasmic sperm injection leads to lower embryo developmental competence compared with when used fresh insemination methods. However, pregnancy and implantation rates become higher when embryos are transferred into a more receptive endometrium, free of the adverse effects of gonadotropin. Moreover, the freeze-all method leads exceptional clinical outcomes. Preservation of female genetics is currently done by primarily means of oocyte and embryo cryopreservation. This field has seen much progress in history, progress predominantly driven by research in humans, mice and cows. Two basic cryopreservation techniques rule this field controlled & rate freezing, the first to be developed and vitrification, which, in recent years, it has gained a foothold. While much progress has achieved in human medicine, the cattle industry and in laboratory of animals. Preservation of female genetics can be done by the preservation of germplasm (oocytes and embryos).
Quality Management in ART: This is easily adoptable ways to implement and improve formalized quality management systems. Essential to achieve the best practices and maintenance of formal regulatory certifications & together to know how experienced opinion leaders operating in key areas worldwide. The primary regulations in the ART field, with attention to quality management demands and the links specific requirements to practical steps for implementation. Unlike most medical laboratories that play a diagnostic role, laboratories for assisted reproductive technologies, ART laboratories, are involved in the treatment of infertile couples. Handling human gametes and producing human embryos in order to achieve much sought of pregnancies form the key tasks of an ART laboratory. The impact of the activities and possible risks makes it necessary to ensure the safety and reproducibility of all methods. To achieve and maintain the highest level of patient care and highest success rates, a quality management system should be implemented. Several guidelines, compiled by professional associations of ART experts, official international standards and quality management models have been developed and issued and will be applied. Irrespective of the choice, establishing a quality management system in an ART leads to a huge amount of additional work and it requires a lot of investment in all kind of areas. However, due to increased standardization and efficiency of all procedures as well as improved transparency and trace ability of all actions performed, the quality of service provided by the ART will improve substantially and the effort will be worthwhile.
Assisted reproductive technology (ART) refers to treatments which involve handling eggs and sperms or embryos outside the body this includes IVF and a few of its variations. These procedures which are usually paired with fertility drugs are to increase success rates and at about 22% of ART procedures result in the birth of a baby. ART procedures are medical procedure, expensive and have side effects. When more than one embryo is placed in the uterus, there is a possibility of a pregnancy with multiples if two or more implants successfully. But in case so far no long-term health effects have been connected to children born using ART procedures, and so many people with fertility problems, ART is the best way of having a biological child
Gamete intrafallopian transfer get involves a direct transfer of human gametes, sperm and oocyte into the fallopian tube. Its role in the treatment of infertile women with patent tubes has been established. Recent data demonstrate that a 34.4% clinical pregnancies are with the highest pregnancy rate achieved in infertile women is due to endometriosis or unexplained infertility. Gamete intrafallopian transfer (GIFT) is the tool of assisted reproductive technology against infertility. This technique allows fertilization to take place inside the woman's uterus. With the advances in IVF the GIFT procedure is used as less as pregnancy rates in IVF which tend to be equal or better and this do not require laparoscopy when the egg is put back. It takes average of 4 to 6 weeks to complete a cycle of GIFT. Firstly, the woman should take a fertility drug to stimulate egg production in the ovaries. Then doctor will monitor the growth of the ovarian follicles, and then once they are mature, the women get injected with Human chorionic gonadotropin (HCG). The eggs will harvested approximately 36 hours later & mixed with the man's sperm, and get placed back into the woman's Fallopian tubes by using a laparoscope.
Obstetrics & Gynecology is the most complete and reliable source of information on current developments in women's health care. According to population projections from the U.S. Census Bureau from 2010 to 2050 and published age-specific prevalence estimates for bothersome, symptomatic pelvic floor disorders and pelvic organ prolapse, the number of women with uterovaginal prolapse is expected gradually to increase from 3.3 to 4.9 million from 2010 to 2050. Whereas complete vaginal eversion is obvious, lesser degrees of prolapse and the presence of enterocele are more difficult to discern and require careful evaluation of all anterior, posterior, and apical compartment defects. Also, associated functional abnormalities, whether concurrent or potential, must be properly explored, evaluated, and discussed with the patient.
Ovulation induction treatments, also referred to as fertility drugs, are used to stimulate follicles in ovaries resulting in production of multiple eggs in one cycle. These medications also control time that you release eggs, or ovulate, so that sexual intercourse, intrauterine inseminations, and in vitro fertilization procedures can be scheduled at the most likely time to achieve pregnancy. Risks associated with use of ovulation induction medications include increase in chance for high order multiple births and development of ovarian cysts. Rare side effect that occurs is ovarian hyper stimulation syndrome, symptoms include severe pain in pelvis, abdomen and chest, nausea, vomiting, bloating, weight gain and difficulty in breathing.
Fertility is the natural ability to produce offspring. As a measure, fertility rate is the number of offspring born per mating pair, individual or population. Population growth is estimated by fertility, mortality and migration rates. Fertility is the main prime determinant of population growth, which is highly associated with family planning, literacy, urbanization, and expansion of health system. In many part its level is more than twice the replacement level. A significant decline in fertility mainly in the urban setting has been reported over the past decade. Total fertility rate was relatively low. However, there were a significant number of births among adolescent women. Improving and sustaining access for reproductive health care for young women is highly recommended. Before starting an in vitro fertilization cycle, some women need help to ovulate and the use of growth hormone therapy may help these women. This main aim to reduce the use of gonadotropin therapy to stimulate ovulation, a hormone which can cause multiple pregnancies. The review found no evidence that growth hormone helps improve birth rates in women who are undergoing ovulation induction prior to in vitro fertilization. However there is some evidence of increased pregnancy and birth rates in women who are considered poor responders to in vitro fertilization.
- Track 29-1Fertility preservation
- Track 29-2Fertility-development controversy
- Track 29-3Family economics
- Track 29-4Family planning
- Track 29-5Sub-replacement fertility
- Track 29-6Birth control
Placentology evolving rapidly to our understanding of the molecular, cellular and epigenetic mechanisms which underlying normal placental development and placental pathophysiology is rapidly increasing and the making opportunities in prediction, prevention and treatment of this condition are expanding likewise. It is the only relatively recently that attention which has been directed to studies of the uterine side of the placenta to look for possible defects that mightexplain otherwise unexplainable pregnancy complications. Preeclampsia and intrauterine fetal growth retardation are the two such disorders in which new information has come to light by study of placental bed biopsies and occasional caesarean hysterectomy specimens. It will be less easy to apply these techniques to such problems as spontaneous abortion and antepartum hemorrhage, but reemphasizing what should be the self-evident importance of the establishment and development of the uteroplacental blood supply might help reorient thinking about these and other important complications of pregnancy. Fresh thoughts are required too about etiology and history of ectopic pregnancy, not so much as its own sake but more because of what it tells us about the nidation and placentation in general. It is now become difficult to insist on stringent criteria for endometrium in human gestation, with all that this implies for the woman under investigation for infertility.
- Track 30-1placenta accreta
- Track 30-2placenta increta
- Track 30-3placenta percreta
- Track 30-4placenta growth factor